A Radioautographic Study of Hemopoietic Repopulation Using Irradiated Parabiotic Rats

A radioautographic study of hemopoietic repopulation using irradiated parabiotic rats. Relation to the stem cell problem.

S EARLY AS 1930, Woenckhausa4 showed that if one of two rats joined in parabiosis was exposed to lethal irradiation, both animals survived. Since that time it has been shown that the recovery of lethally irradiated animals may also be attained by shielding bone marrow29 or spleen27 or by transfusing the irradiated animals with large numbers of blood leukocytes.203 ’ : 6,44,49 The use of chromos...

Study of Hemopoietic Repopulation Using Irradiated Parabiotic Rats Relation to the Stem Cell Problem

S EARLY AS 1930, Woenckhausa4 showed that if one of two rats joined in parabiosis was exposed to lethal irradiation, both animals survived. Since that time it has been shown that the recovery of lethally irradiated animals may also be attained by shielding bone marrow29 or spleen27 or by transfusing the irradiated animals with large numbers of blood leukocytes.203 ’ : 6,44,49 The use of chromos...

Study of Hemopoietic Repopulation Using Irradiated Parabiotic Rats Relation to the Stem Cell Problem

S EARLY AS 1930, Woenckhausa4 showed that if one of two rats joined in parabiosis was exposed to lethal irradiation, both animals survived. Since that time it has been shown that the recovery of lethally irradiated animals may also be attained by shielding bone marrow29 or spleen27 or by transfusing the irradiated animals with large numbers of blood leukocytes.203 ’ : 6,44,49 The use of chromos...

Radioautographic study of cellular migration using parabiotic rats.

Carcinoma of the prostate in irradiated parabiotic rats.

Twelve hundred fifty-two pairs of male NEDH rats were parabiosed, one partner received a single dose of 1000 R X-radiation, and the other rat was shielded with lead. Eleven hundred twenty pairs survived over 200 days and constitute the basis of this report. Twenty-five of the irradiated partners developed malignant tumors of the prostate, 19 of which were adenocarcinomas. One adenocarcinoma app...